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As a brief introduction, binding of epidermal growth factor (EGF) to the extracellular domain of the EGF receptor (EGFR) leads to the assembly and activation of NADPH oxidase (Nox) that, in turn, generates endogenous H 2 O 2 [60]
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Furthermore, positive correlations were observed between CYP2E1 promoter methylation and both iNOS promoter methylation and urinary levels of SPMA
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