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Addiction and substance use care

Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy

K., Weinstein, D

Increased ROS levels modulate transcription factor activity, especially NF-B, activator protein-1 (AP-1) and the peroxisome proliferators-activated receptor (PPAR) family of transcriptional activators ( As a result of increasing ROS generation, one of the first events in atherogenesis, as well as in other CVDs correlated with endothelial dysfunction, is the oxidative modification of low-density lipoprotein (LDL) (Singh et al., 2002