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P53-induced activation of antioxidant genes enhances the cellular antioxidant capacity, which is substantiated by increased synthesis of reduced glutathione (GSH), production of NADPH, and detoxification of electrophiles and oxidants

For example, it reduces 7-ketocholesterol-induced endothelial damage, suppresses pro-inflammatory cytokines, and preserves tight junction protein integrity in a brain microvascular endothelial hCMEC/D3 cell line [20]

[Abstract]2025 Oct;18(10):e70254
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