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Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose

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This makes B12 supplementation extremely safe, with a low risk of toxicity

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When a patient receives an injection during an office visit, Medicare and many private insurers apply specific rules to determine whether separate payment for both services is appropriate

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