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The ligand occupies the ATP binding site of c-Met, competes with ATP by forming hydrogen bonds with Met 1160, and binds with Asp 1222 in the active region of c-Met to form hydrogen bonds, thus producing strong kinase inhibitory activity (Fig

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X-ray crystallography provides a structural rationale for photoactivation in photocobilins To provide a structural rationale for the photocobilin photo-sensing properties, we determined the crystal structures of the dark (PDB 8J2W) and light-adapted states (PDB 8J2X) of Sas Pcob, as well as the dark state of the isolated Ab DPcob photoreceptor domain ( Ab Pcob, PDB 8J2Y), at 1.7 ;, 2.0