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In this paper, compounds were described that activate SOS-mediated nucleotide exchange and paradoxically inhibit downstream RAS signalling
In the promoter region, G alleles of rs9932581 and T alleles of rs8854 are associated with increased promoter activity, resulting in elevated oxidative stress (Tupurani et al., 2018)

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doi: 1 10.1002/ajmg.a.37880
