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The colonic barrier breakdown thus allows microbial derivation products, whose most common representatives should be considered LPS and Teichoic acid (TA), to begin to translocate into the layer underneath the epithelium, the lamina propria, launching an immune challenge that will express itself through numerous pro-inflammatory cytokines and complex-associated cascades (82, 88)

7.1.1.1 Monoclonal antibodies Antibodies targeting specific cytokines, such as TNF- inhibitors (e.g., infliximab and adalimumab), have been shown to decrease the levels of systemic inflammation and reduce BBB dysfunction (Gu et al., 2021)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 253.Zhao J., Kobori N., Aronowski J., Dash P.K