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Activated microglia and astrocytes release proinflammatory cytokines including tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and interleukin-1 (IL-1), creating a hostile neuroimmune milieu ( In PD brains, persistent glial activation is associated with regions of dopaminergic degeneration, indicating a spatial correlation ( Epigenetic regulation also influences proteostasis in PD

The presence of pyrrolizidine alkaloids in BP can create severe conditions of lung cancer and hepatotoxicity, which are strongly related to the botanical origin of BP

While glutathione is a powerful antioxidant and theoretically could reduce oxidative stress in melanocytes, there is no robust clinical data showing that increasing dietary or supplemental glutathione can reliably prevent or reverse gray hair in humans. The bodys regulation of hair pigmentation is complex, he added, and once melanocytes lose their ability to produce pigment, antioxidants alone are unlikely to restore it