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Calcaterra V, Rossi V, Massini G, Casini F, Zuccotti G, Fabiano V

Because of the high penetrance and aggressive nature of this malignancy, patients identified with a known RET mutation should undergo a prophylactic thyroidectomy early in life to prevent metastatic disease
The release of iron ions by lysosomes through the degradation of ferritin mediated by autophagy increases intracellular free iron ion content, thereby promoting ferroptosis [6, 77, 78]

3a), CYP27A1 (Fig