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Overproduction of ROS and induction of oxidative stress are major contributors to OA pathogenesis [13]

The therapeutic effects of statins are attenuated by abundant presence of Lactobacillus, Eubacterium, Faecalibacterium , and Bifidobacterium and decreased proportion of genus Clostridium [5], which renders these drugs relatively ineffective in decreasing LDL levels

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There are several literature data examples reporting on such interferences in CRP and other tests