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The lower lip, in particular, receives years of unprotected sunlight in most people because lip sunscreen is rarely applied with the same diligence as facial sunscreen

These effects are mediated by the phosphorylation of downstream signaling molecules, including ribosomal protein S6 kinases (S6Ks) that regulate global protein synthesis, ULK-51-like kinase 1 (ULK1) that is involved in initiating macroautophagy, and eukaryotic translation initiation factor-4E (eIF4E)-binding proteins (4E-BPs) that control cap-dependent translation (117)
ADCY3 = adenylate cyclase 3
