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1 Introduction It is estimated that between 1,000 and 1,150 different types of microorganisms reside in the human gut ( Firmicutes , Bacteroidetes , Proteobacteria , Actinobacteria , and Verrucomicrobia , dominate the gut microbiota in healthy people, which maintains a very consistent composition ( Numerous research conducted in recent years have shown how the gut microbiota and its metabolites influence the development of both cardiovascular and non-cardiovascular diseases in the host, including inflammatory bowel disease, colon cancer, hypertension, heart failure, and stroke ( 2 Gut microbiota mechanisms of action in cardiovascular diseases The gut microbiota might influence cardiovascular disorders through metabolites like short-chain fatty acids, trimethylamine-N-oxide, coprostanol, bile acid, indoxyl sulfate, phenylacetylglutamine, and vitamin K2 (Figure 1)