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The enzyme system that catalyzes the cleavage reaction is known as P450-linked side chain cleaving enzyme (P450ssc) or 20,22-desmolase, or cholesterol desmolase, The P540ssc enzyme is localized to the inner mitochondrial membrane of steroid-producing cells, but not in significant quantities in other cells

Folic acid plus alpha-tocopherol mitigates amyloid-beta-induced neurotoxicity through modulation of mitochondrial complexes activity

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It was isolated from tissue of the thymus gland for the first time in 1972 and has been used in treating