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Besides the nuclear function, p53 located in cytoplasmic also promotes apoptosis through directly targeting mitochondria (reviewed in Marchenko and Moll, 2007)
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For a calculator-style walkthrough, use the peptide reconstitution guide
10.1016/j.nbd.2014.12.025 105 RumiJ.MarmolF.SanchezJ.Gimnez-CrouseillesJ.CarreoM.BargallN.et al (2013)
