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Similarly, the expression of multidrug resistance-associated protein 2 can reduce intracellular cisplatin levels by effluxing the drug, thereby diminishing its efficacy (60)

In Clostridioides difficile infection (CDI), MBK-01 (NCT05201079) and VE303 (NCT06237452) are leading Phase 3 candidates demonstrating efficacy and safety over fidaxomicin or donor-derived FMT (Reigadas et al., 2020)

Nutrient-regulated phosphorylation of ATG13 inhibits starvation-induced autophagy

Observations that patients on statins have decreased CoQ10 concentrations in muscle cells (25) resulted in efforts to evaluate CoQ10 for statin-induced myalgias, but data are inconclusive (26) (27) (28) (45) (52)