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Metabolic generation of L-carnosine from N-acetylcarnosine requires adequate bioactivity of the lens enzyme system

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Through KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis of the genes identified by positive screening, we found that genes related to the Wnt signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway or encoding ABC transporters, all of which have been reported to play key roles in mediating CDK4/6i resistance, were significantly enriched in the CDK4/6i treatment group (Fig