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1 Introduction Parkinsons disease (PD) is a chronic progressive and extensive degenerative disease of the extrapyramidal nervous system that can cause motor symptoms (tremor, muscle rigidity, bradykinesia/slow movements, and postural instability) as well as non-motor symptoms (neuro-vegetative, psycho-cognitive/dementia, pain/sensory, and/or sleep disturbances) ( Parkinsons disease is a multisystem disorder, a consequence of multi-neuropeptidergic dysfunction, which includes dopaminergic, serotoninergic, cholinergic, and noradrenergic systems

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