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Smith DM, Schafer JR, Tullius B, Witkam L, Paust S

To illustrate the relative consistency of these effects across evidence streams, a composite heatmap of major endpoints is shown in Figure 3, highlighting oxidative stress, mitochondrial dysfunction, inflammation, and cell death as the most robustly supported toxicological pathways

AOD-9604 corresponds to residues 177191 of the C-terminal region of the 191-amino-acid human growth hormone molecule, with one deliberate modification: a tyrosine residue is added at the N-terminus to improve the fragments stability and handling

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