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In response to cold exposure, GDF15 secreted by BAT targets macrophages to suppress the expression of proinflammatory genes

In view of these important functions, carnitine is increasingly detectable, particularly in tissues such as the skeletal and cardiac muscles, which use fatty acids as a food fuel

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Similarly, topiramate decreased its MDA levels and increased GSH levels in a study on the prevention of flap necrosis after plastic and reconstructive surgery ( However, in a study on the potential toxic effects of topiramate on the liver and kidney of male mice, topiramate significantly decreased the activities of the antioxidant enzymes SOD and CAT, while increasing MDA and NO levels ( In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)