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Due to their heightened metabolic activity, RPE cells harbor an abundance of mitochondria and consequently represent a major source of ROS [360]
However, recent studies have discovered neurodegenerative components of the disease such as insidious axonal degeneration and neuronal atrophy, which seem to be the histopathological correlates of progressive clinical disability in MS patients [90]
p53 induces the expression of TIGAR, and thus slows glycolysis 7
10.3390/ijms16059236 390
