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Expression of Thymosin Beta-4 has been observed to increase during early angiogenesis, and research suggests that the peptide may promote endothelial migration and vessel remodeling

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Pacifico A, Damiani G, Iacovelli P, Conic RRZ, Gonzalez S, Morrone A Young Dermatologists Italian Network (YDIN) NB-UVB plus oral Polypodium leucotomos extract display higher efficacy than NB-UVB alone in patients with vitiligo

4.5 GM-Based Interventions: Potential Use as Disease-Modifying and Preventive Treatments To date, studies testing GM-based interventions have been conducted in groups of patients with manifest PD, with the main goal to treat symptoms

Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects