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The isoconstrictive vascular substances such as isoprostaglandin and 8-iso-prostaglandin F2 could also be released from cochlear vascular system and the Cortis organ ( + ions, leading to depolarization of membrane potential and abnormal influx of Ca 2+ , which is termed as calcium overload (Vicente-Torres and Schacht, 2006

Pharmacol Res 177:1 Xing C, Zhang C, Wang W, Wu L, Xing C (2020) Sleep disturbance induces increased cholesterol level by NR1D1 mediated CYP7A1 inhibition

doi: 10.1185/030079906X132488

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