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In particular, the authors used poly(butyl cyanoacrylate)-based micro-bubbles loaded with IONPs that can mediate the BBB penetration
Li, Nanoscale 7, (2015) 88118818

Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S et al (2018) Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
