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When glutamate is released from excitatory neurons, it stimulates type I and V metabotropic glutamate receptors (mGluRs) in astrocytes, the activation of which induces elevation of the astrocytic [Ca 2+ ] i , which in turn triggers glutamate release from astrocytes

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515 Conversely, if feedback control is compromised due to sensory deficits or impaired reflex pathways, the CNS may increase feedforward activation in an attempt to stabilize the joint preemptively

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