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miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression

10.1042/cs20160935 125 KuriakoseM

Experimental studies have shown that oral supplementation with glutamine can significantly decrease the severity of chemotherapy-induced stomatitis, an important cause of morbidity in the treatment of patients with cancer,[85,86] although the dose given and duration of therapy varies widely upon pathological conditions.[87] Other modalities of prevention of chemotherapy-induced mucositis, like oral cooling, granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor and laser, are available, none of them have uniform efficacy.[88] Studies in mice suggest that alanyl-glutamine, not glutamine, speeds intestinal recovery when compared in 5-FU-treated mice, predominantly by enhancing mitotic activity and crypt length.[89] To evaluate the effect of therapeutic interventions in patients with chemotherapy-induced mucositis, testing intestinal permeability via the measurement of[51] Cr-EDTA urinary excretion after oral challenge may be useful as shown in some experiments.[90,91] GLUTAMINE AND PROTECTION AGAINST ANTHRACYCLINE-INDUCED CARDIOTOXICITY Glutamine supplementation maintained cardiac GSH levels in animal models given methotrexate or CP
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