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Although pentosan polysulfate is an approved treatment for interstitial cystitis, some patients on this medication experience treatment failure after one year, and its long-term use has been linked to pigmentary maculopathy
Combination anti-TNF-alpha and thiopurine therapy increases the risk of serious opportunistic infections and hepatosplenic T-cell lymphoma

doi: 10.1111/bph.12127

Altieri MA, Nicholls CI, Henao A, Lana MA (2015) Agroecology and the design of climate change-resilient farming systems
