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All enzymes in the periplasm are ATP-independent, due to the lack of ATP in this cellular compartment

linked dihydroartemisinin to a multi-armed PEG, and this coupling increased the dihydroartemisinin loading capacity, enhanced the water solubility, and increased the half-life of the drug in blood circulation, resulting in better inhibition of tumor growth (Kumar et al., 2019)

We postulate that boosting mitochondrial metabolism might be a potential therapeutic strategy to induce antidepressant effects

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