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In line with these observations, induced degradation of endogenously Halo-tagged TRF1 reduced telomere association of overexpressed TIN2 and POT1 but not TRF2, which is proposed to form a separate subcomplex with RAP1 47

However, therapies targeting xCT, such as xCT inhibitors and targeted xCT vaccines, have been utilized in the treatment of exogenous cystine-dependent cancer cells (65)

Some ecological studies have demonstrated a connection between vitamin B use and obesity and diabetes prevalence

To mimic the reductive half reaction, a glutathione moiety was covalently attached to the active-site cysteine via a disulfide bond in all systems