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While the efficacy of ICA-1s is well documented in-vitro , it has not been tested in-vivo 1,3,12

In Canada, synthetic injectable peptides are generally regulated as prescription drugs under the Food and Drugs Act, and Health Canada has issued public advisories (April 2026 and earlier) cautioning that unauthorized injectable peptide products are illegal regardless of whether they are labelled 'for research use only.' Research-grade AOD-9604 supplied by Koipeptides is intended for in vitro laboratory study only and is not authorized for any human or veterinary application

doi: 10.1016/j.taap.2010.04.011

Editor: Shahrad Taheri, Weill Cornell Medical College in Qatar, QATAR Received: May 4, 2015