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Although the knockout of GPX7 does not lead to the direct death of mice, the production of excess reactive oxygen species leads to incorrect oxidative modification of proteins and irreversible changes in function, resulting in various diseases

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CHB is also characterized by T-cell exhaustion, which is worsened by alcohol and includes up-regulation of PD-1, CTLA-4, and TIM-3 (66), impaired mitochondrial function in T cells (23, 67), and impaired antigen-presenting function of dendritic and Kupffer cells (6870)