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However, this is purely theoretical at this point, and much more research is needed to determine the optimal dosing, administration protocols, and potential interactions of these compounds in human patients

1 2 "Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review"

Onset of efficacy of long-acting psychostimulants in pediatric attention-deficit/hyperactivity disorder

For most patients, the first dose is administered in the week preceding further therapy, with follow-ups every few weeks to help alleviate symptoms and support better health outcomes
