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A total of 50 participants (men and women, 3560 years of age) with dry skin, skin moisture content of 49% or less, or crows feet greater than grade 3 were tested for 12 weeks in this double-blind, randomized, parallel, placebo-controlled study (equal numbers of subjects were in the APCP or placebo groups)

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A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets