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Increased superoxide anion formation in endothelial cells during hyperglycemia: An adaptive response or initial step of vascular dysfunction?Diabetes Res Clin Pract

Elesclomol (ES) and Disulfiram (DFS) induce apoptosis by transporting copper ions into cells and mitochondria, resulting in the oligomerization of dihydrolipoamide s-acetyltransferase, decreased stability of Fe-S clusters and interaction with Npl4 (Reeder et al., 2011)

doi:10.21608/ejh.2020.45532.1369

Mechanistically, loss of LCN2 suppressed Wnt antagonists DKK1 and SOST and enhanced Wnt/-catenin signaling, leading to increased osteoblast-mediated bone formation