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Research suggests that inhibiting PARP1 can enhance the functionality of senescent cells by increasing NAD + levels and SIRT1 activity 159

There have been multiple criminal charges levied against the founders, including distributing unapproved drugs after a warehouse raid from the FDA, but all charges were dropped by 1996.15 Then, in 2017, Life Extension was issued a warning for claiming that its products could cure diseases such as breast cancer.16 Because the FDA doesn't regulate supplements, its illegal for companies like Life Extension to claim that supplements will treat, diagnose, prevent, or cure diseases.17 Most recently, in April 2023, Life Extension was named as a recipient of the FTCs Notice of Penalty Offenses Concerning Substantiation of Product Claims