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This review fails to resolve some issues and requires further research and refined methodology to provide evidence for the natural compounds therapeutic efficacy

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The RNA yield was determined using a NanoDrop 2000 Spectrophotometer (Thermo Scientific, Waltham, USA), and the integrity was evaluated using agarose gel electrophoresis with ethidium bromide stain

After a 3-day CR control diet, Cse / and Cse +/ mice were shifted to either CR control, CR no-Cys or CR tryptophan-free (no-Trp) diets, and tissues were collected after 2 days