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The in vivo studies also support this main pharmacological mechanism of ARS, with no toxicity at high doses, in contrast with much more toxic corticosteroids which are often refused by parents for their children with DMD

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They are primarily considered for research and are often used "off-label" in clinical settings

This precursor molecule can scavenge ROS in both direct and indirect manners by penetrating the cell membrane and reacting with glutamic acid and glycine to form glutathione, intracellularly