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(2000) Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C

The first and best-characterized mechanism is the AMPK pathway
Sick goats may lose weight, produce less, breed poorly, or require repeated treatment

Evidence: Systematic review shows B12 significantly improves diabetic neuropathy symptoms vs placebo (Hasan et al., 2019)
