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However, these compounds have been confirmed to have significant neuroprotective and preventive activity in OIPN preclinical and clinical data [186, 187]

Also, with increased research interest in immunotherapies, it is important to resolve issues limiting the clinical efficacy and safety of these treatment approaches

102 Some non-classical Wnt ligands can activate non-canonical pathways such as Wnt/planar cell polarity (PCP) and Wnt/Ca + pathways, playing different roles
