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The pathophysiology is mainly manifested in the decrease of NPCs and the imbalance of synthesis and degradation of ECM of IVD
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not led to a marked increase in histone H2B ubiquitination at the tim and Pdp1 gene loci ( Nipped-A (the Drosophila ortholog of the human schizophrenia-associated gene TRAPP), the histone acetyltransferase component of the SAGA complex (Mahesh et al., 2020)
