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Radiotherapy inhibits tumor growth by generally inducing tumor cell apoptosis, necrosis, mitotic catastrophe, autophagy, or senescence through inflicting extensive DNA damage, including DNA-protein crosslinking, or transiently increasing the levels of cytotoxic reactive oxygen species (ROS) (Chen and Kuo, 2017)

Int Immunopharmacol 117:109969 Hatada EN, Krappmann D, Scheidereit C (2000) NF-B and the innate immune response

Nevertheless, since omega-3 fatty acids and their metabolites might modulate pivotal molecular pathways including metabolic routes for the three amino acids (cysteine, glycine, and glutamate) needed for GSH biosynthesis, this feature could represent a promising field of knowledge to be explored

This phenomenon is explained by the BurtonIngold hypothesis, whereby -carotene shifts from an antioxidant to a pro-oxidant under high oxygen tension, as found in the pulmonary environment of smokers