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10.22038/ijbms.2021.54800.12291 75 SubermaniamK.TeohS

Thus, whether TMAO is an atherogenic factor responsible for the development and progression of cardiovascular disease, or simply a marker of an underlined pathology, remains unclear [85]

The Mendelian randomization analyses performed in four population-based cohort studies found an inverse association between the results of coronary heart disease, stroke, and all-cause mortality with a low serum concentration of this vitamin [92]

The incidence of drug-related adverse events , mainly mild gastrointestinal and obstetrical complications, was slightly more frequent in the placebo arm (lactose intolerance) and resolved rapidly (Table 1B)
