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Real-world data from three national registries (Switzerland, Ireland, and Austria) have recently been published, comprising a total of 615 patients with alpha-1 antitrypsin deficiency (97.7% with the ZZ genotype)

Data Availability Statement The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families

This toxin rapidly and violently depletes the liver's entire storage of glutathione, leading to acute, life-threatening liver failure and hepatic necrosis within hours