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doi: 10.1146/annurev.ph.56.030194.000521 21
GSH inhibits GCL by competing with glutamate in the active site of GCLC (1, 5760)
Nature 355 (6357), 273275
39 In addition, the reactive aldehydes such as acrolein and 4-hydroxy-2-nonenal (4-HNE) formed from lipid peroxidation cause damage to the epithelial cells, acrolein is unstable and toxic, whereas 4-HNE in high concentrations is capable of inducing caspase (a major promoter of cell apoptosis)
