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The long non-coding RNA MALAT1 activates the NRF2 transcription factor, enhancing the expression of antioxidant genes such as HO1, NQO1, and GCLC, which helps protect cells from oxidative stress-induced damage [167]

This suggests it serves a critical protective role in mitigating DNA damage and supporting long-term mitochondrial health

The FinnDiane study found a significant familial risk for proliferative retinopathy, with an odds ratio of 2.76 for siblings of probands, highlighting the importance of genetic factors in DR (Maghbooli et al., 2014)

(For additional information on the establishment of our budget neutrality policy for changes to the area wage level adjustment, we refer readers to the FY 2012 IPPS/LTCH PPS final rule (76 FR 51771 through 51773 and 51809).) For FY 2024, in accordance with 412.523(d)(4), we are applying a proposed area wage level budget neutrality factor to adjust the LTCH PPS standard Federal payment rate to account for the estimated effect of the adjustments or updates to the area wage level adjustment under 412.525(c)(1) on estimated aggregate LTCH PPS payments, consistent with the methodology we established in the FY 2012 IPPS/LTCH PPS final rule (76 FR 51773)