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Different types of OFF episodes can occur, including upon awakening (morning OFF or morning akinesia), at the end of a CD/LD dose (wearing OFF), with delay in onset of effect from a CD/LD dose (delayed ON), with failure of a CD/LD dose (suboptimal ON, dose failure), and unexpectedly, without an apparent dose relationship (unpredictable OFF) [1, 6]

A study of 22 adults with mild-to-moderate acne showed that applying 35 drops of serum containing 0.5% silymarin twice daily for 4 weeks reduced the number of lesions from 14.0 to 10.5 and decreased acne severity by 3.04 points (on a 024 scale)

Study on efficacy of liujunzi decoction combined with zuojin pills in treating acute radioactive duodenitis and their mechanism