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PIK3C3 kinase is essential for autophagosome formation via complex I (PIK3C3PIK3R4ATG14 (autophagy related 14)BECN1 (beclin 1)) and for the establishment of the endosomal compartment via complex II (PIK3C3PIK3R4UVRAG (UV radiation resistance-associated gene)BECN1nuclear receptor binding factor 2 (NRBF2))

Nobuyasu Suganuma (Department of Surgery, Yokohama City University)

Because glutathione does not cross the bloodbrain barrier other treatment options to increase brain concentrations of glutathione including glutathione analogs, mimetics or precursors are discussed.

Second, how to reduce the Pt accumulation in the peripheral nervous system is extremely critical to prevent, treat, and even overcome the PIPN