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There was also a significant increase in urine of m+3 orotate, which is derived from pyruvate carboxylation to oxaloacetate, demonstrating another mechanism by which Cse / mice can waste carbon in the absence of CoA (Extended Data Fig

Calder, 2020)

Pseudoatrophic Macules: A Variant of Neurofibroma
2016;311:L881L92
