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Description
2.3.4 P53 signaling pathway Recently, P53 was discovered to promote cellular ferroptosis by regulating the expression of ferroptosis- related genes Earlier research has indicated that P53 interacts with P53 response elements in the SLC7A11 gene promoter region, suppressing SLC7A11 expression and enhancing the vulnerability of cancer cells to ferroptosis (56)
References Steven Habusta AF, Coffey R, Ponnarasu S, Mabrouk A, Griffin EE
This metabolic flexibility allows AML cells to adapt to different microenvironments and resist chemotherapy
2019;5:Cd001287
