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197 The upregulation of claudin-2 upon ERK1/2 activity was also reported in mouse rectal CMT93-II cells
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At present, NNMT and CYP2E1 are the only two enzymes that act as NAM clearance enzymes [7], and both of them are classified into ADME genes which are involved in drug Absorption, Distribution, Metabolism, and Excretion by the PharmaADME Consortium ( [104]
