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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Ycel M, Wood SJ, Wellard RM, Harrison BJ, Fornito A, Pujol J, et al

Woman silhouette with highlighted internal organs - Image Credit: Designua / Shutterstock Mechanism of action Estradiol binds to specific receptors in the target cell, and subsequently enters the nucleus to induce the formation of messenger RNA

the first is the inositol-requiring enzyme 1 (IRE1), IRE1 is the main isoform, which presents phosphorylase activity and endoribonuclease activity, causes mRNA degradation and the alternative splicing of X-box binding protein 1 (XBP1s) upregulated the expression of the machinery for protein synthesis and factors related to protein degradation (Maly and Papa 2014)